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Still, high doses can act as prooxidants, meaning they might generate reactive oxygen species under certain conditions

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The CDC reports that in 2019, there were approximately 61,000 TBI-related deaths in the U.S

FIGURE 3 NO in cartilage and synovium is produced by iNOS, which mediates the expression of inflammatory factors, inhibits the synthesis of collagen and proteoglycan, and induces chondrocyte apoptosis and pain (Suantawee et al., 2015)