Max Denning at Eli Lilly, who's a senior medical director at the company and worked on studying the new pill
In light of our recent findings, it seems plausible that the stimulation of GLP-1 by whole cells is a key mechanism behind those effects. Its also important not to get carried away with the potential of food-based GLP-1 receptor agonists to help those in need of medical intervention
However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209
Quality controls 99% HPLC purity, mass-spectrometry identity confirmation (BPC-157 expected mass ~1419.5 Da), and explicit endotoxin status are the four data points to verify per batch regardless of supplier
With the current absence of technologies to rectify the actual mutations that underlie mitochondrial diseases, medical science can only address the resulting oxidative stress as a potential therapeutic option