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In vitro studies of colorectal cancer have demonstrated that HDACi effectively inhibits cancer cell proliferation and induces apoptosis

Dysfunctional regulatory factors such as mucins, antimicrobial molecules, cytokines, and immunoglobulins (Igs) are often responsible for impaired barrier integrity that may lead to, or exacerbate, inflammatory diseases including type-1 diabetes (T1D), multiple sclerosis, autoimmune hepatitis, systemic lupus erythematosus (SLE), IBD, and coeliac disease (CD) (Fasano and Shea-Donohue 2005

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In this study, mice were injected into the ears with either 750,000 or 25,000 human A375 melanoma cells, followed by a 2-day treatment, starting 24 h later, with either saline (control group), ES2 peptide, dabrafenib (a senescence inducer), or a combination of ES2 and dabrafenib [128]