They are susceptible to degradation pathways that small molecules simply do not face, including deamidation, oxidation, aggregation, and hydrolysis
The study results, published in the July 15, 2026, online edition of The Lancet Gastroenterology & Hepatology , address a major unmet need for people with metabolic dysfunctionassociated steatohepatitis (MASH), a serious form of fatty liver disease that can lead to cirrhosis, liver failure, and the need for transplantation
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Yang W.H., Qiu Y., Stamatatos O., Janowitz T., Lukey M.J
10.1093/ajcn/nqab152 Am J Clin Nutr