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Since 2005, two new classes of drugs based on incretin action have been approved for lowering blood glucose levels in T2DM: an incretin mimetic (exenatide, which is a potent long-acting agonist of the GLP-1 receptor) and an incretin enhancer (sitagliptin, which is a DPP4 inhibitor)
Beyond calcium signaling, BDNFTrkB-T1 interactions also regulate astrocytic function by modulating the activity of the GABA transporter GAT-1, thereby influencing GABA uptake dynamics [352]
There are no side effects reported
However, these medications can significantly impact the safety of anaesthesia delivery through their effect on gastric emptying, which is a critical consideration in anaesthetic practice
