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Serum creatinine and the Child-Pugh score were independent predictors of death.14 In another study with patients with normal fasting glycaemia subjected to OGTT, the 5-year survival rate was lower in patients with IGT or DM.15 Another study found that the cumulative 5-year survival rate of those with abnormal OGTT values or overt DM was significantly lower.16 Our group recently reported that abnormal OGTT was associated with a significant increase in mortality at 5 years

The intermediates from de novo lipogenesis in the liver will disrupt mitochondrial function and produce ROS, and then cause endoplasmic reticulum (ER) stress, ultimately leading to inflammation, and the broken cells releasing cytokines will cause more cell death ( The excess free fatty acids (FFAs) and de novo lipogenesis would break the homeostasis of lipid metabolism

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So, it features less often in combined formulas