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These factors are then mapped onto Bronfenbrenners framework, featuring microsystems such as family/school, mesosystems such as parent-provider interactions, exosystems such as caregiver work conditions, macrosystems such as health policies, and chronosystems such as developmental changes

Another key takeaway is that the benefits are all standardized to a benchmark

However, in children with Down syndrome, one study found red blood cell folate was lower than serum folate

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This variability in outcomes likely stems from differences in study design, population characteristics, and follow-up duration