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Semaglutide set the threshold at -15% in 2021, tirzepatide raised it to -21% in 2022, and retatrutide pushed it to -29% by the end of 2025

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CrossRef BMI Course Over 10 Years After Bariatric Surgery and Biopsychosocial Complexity Assessed with the INTERMED: a Retrospective Study Yann Corminboeuf, Beate Wild, Catherine Zdrojewski, Dieter Schellberg, Lucie Favre, Michel Suter, Friedrich Stiefel Obesity Surgery.2021