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From the anesthesiologist point of view, the growing number of patients treated with incretin-based therapies undergoing deep sedation and general anesthesia uncover the possible dark side of these drugs such as revealed by many case reports documenting the association between general anesthesia and gastric aspiration of a large amount of gastric content (including undigested food particles) in patients taking GLP1-RAs during the peri-operative period [10,11,12]

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