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The most prominent effects of this combination, FOS+GOS, include diminished baseline and stress-induced corticosterone and a decrease in splenic IL-6 and TNF- levels under chronic stress (Burokas et al., 2017)

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Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP

The medication diminished oxidative stress indicators such as 8-hydroxyguanosine (8-OHdG) and suppressed microglial activation in COH mice, but not in DBA/2J animals