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The titration schedule used in clinical trials (slow, stepwise dose increases over multiple weeks) is specifically designed to minimize the intensity of these early side effects

These revealed particular distinctive relations between the activities and inactivity of NO agents

doi: 10.1111/cns.12170

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62 In addition to liver injury and cirrhosis, NAFLD is a major risk factor for primary liver cancer HCC and, in addition to hepatitis virus infection, accounts for the rapid rise in the incidence of HCC in Western countries