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The murine model and the explanted heart showed intra-myocyte iron deposition, fibrosis, hypertrophy, oxidative stress, remodeling of Ca 2+ cycling proteins, and metabolic kinases typical of heart failure

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What matters clinically is that these pathways function together , within a broader physiological system

Still Life with Cheeses, Floris Claesz Van Dijck, 1610, shows how healthy diets are not so modern