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[2] [10] The low risk of hypoglycaemia when used as monotherapy or with metformin is another important benefit, as the glucose-dependent mechanism of insulin secretion means these medicines do not typically cause dangerously low blood sugar levels

In contrast to phenobarbital, however, neither centrilobular hypertrophy nor proliferation of smooth endoplasmic reticulum was evident in the enlarged livers (Makino et al

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SGLT-2 inhibitors are antihyperglycemic agents that target SGLT-2 proteins expressed in the proximal convoluted tubules of the kidneys, where they normally mediate the reabsorption of glucose from the urine