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Bookshelf ID: NBK557767 Diana P (2007): Tetrabenazine in the treatment of Huntingtons disease
4 Vitamin B3 Vitamin B3, commonly known as niacin, is predominantly found in meats, cereals, dairy products, fish, and eggs, and the recommended daily intake for niacin ranges from 15 mg/day to 20 mg/day for humans ( Niacin is crucial for the biochemistry of the nervous system, playing a significant role in energy metabolism, antioxidant activities, and the synthesis of essential molecules for neuronal function, such as acting in dopamine synthesis ( Nicotinamide adenine dinucleotide (NAD) is a co-substrate for various enzymes, such as sirtuins, polymerases, and cyclic ADP-ribose synthesis ( Niacin also contributes to the synthesis of neurotransmitters, such as serotonin, a derivative of tryptophan, which is pivotal for mood regulation and various neurological functions, such as sleep and appetite, besides impacting cognitive and executive functions (50)
Overall, glutathione is considered to have a favorable safety profile when used as directed, but the long-term safety of high-dose or chronic use has not been fully established
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This growing public health challenge highlights the limitations of existing therapies and the pressing demand for disease-modifying treatments that go beyond symptomatic relief (Wang et al., 2024)
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