There are hundreds of other non-protein-associated amino acids which combine in unique ways to perform a number of functions beyond protein synthesis, including tissue growth and repair, central nervous system and neurological function, gut integrity, immune health, gene expression regulation, and detoxification
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By contrast, MAMP/translocation axes act as punctate, contextual danger cues whose benefits are maximized when (i) structural agonism is favorable (for example, hexa-acylated LPS), (ii) exposure can be localized (tumor or draining nodes), and (iii) the engaged PRR skews toward antitumor immunity (for example, NOD2 over NOD1 in CRC)
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