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Glutathione in health and disease: pharmacotherapeutic issues

This dynamic response suggests that upon TCR activation, T cells undergo rapid rewiring of their sterol metabolism, which is characterized by increased sterol synthesis and uptake to support membrane synthesis during T cell expansion

Also, studies carried out in cancer-associated fibroblasts derived from breast cancer patients show that the GPER-1/EGFR signaling axis increases the expression of several cell cycle regulatory genes (Pisano et al., 2017)

These changes coincided with decreased antioxidant pathways (system xc-, glutathione peroxidase 4, and glutathione) and increased lipid peroxidation

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