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2.2 GLP-1R and tau protein hyperphosphorylation Hyperphosphorylated tau is a major component of intracellular neurofibrillary tangles (NFTs), which, together with amyloid plaques, are a distinguishing marker of AD (Tracy et al., 2022

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In addition, GLP-1R overexpression results in improved cognitive function in mice and GLP-1R knockout severely impairs cognitive ability (117, 118)

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