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That approach flagged variants of two genes - GLP1R and GIPR - both of which are directly targeted by the drugs that mimic the effects of our natural gut hormones

Patients who have undergone SG also have elevated GLP-1 levels, though not as high as those seen after GB [13, 15]

So Why Are They Still Being Studied

Impact of dietary habits, ethnicity, and geographical provenance in shaping human gut microbiome diversity

As noted above, in late 2023 the FDA moved 17 peptides popular among longevity enthusiasts BPC-157, TB-500, and others into Category 2, banning them from compounding, while a gray market of self-proclaimed RUO sellers continued operating behind disclaimers the FDA does not recognize for these products as they are being promoted