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There is strong evidence from randomised cardiovascular outcome trials (CVOTs) that several long-acting GLP-1 RAs (liraglutide, dulaglutide and subcutaneous semaglutide) provide cardiovascular protection to individuals with T2D with pre-existing cardiovascular disease (secondary prevention) or at high risk of CV events, and to a lesser extent those without overt atherosclerotic vascular disease (primary prevention

"Wegovy Pill Prescribing Information." Wegovy.com, 2025

In June 2025, 21 similar complaints were filed in New Jersey state court seeking consolidation into a multicounty litigation

These fluctuations can affect GLP-1 medication effectiveness, causing periods of strong appetite suppression followed by periods where the medication seems to stop working