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Sevoflurane offers protection to the glycocalyx, with patients in the sevoflurane group exhibiting significantly reduced concentrations of glycocalyx markers in the blood (such as SDC-1, HS, and HA) and enzymes responsible for glycocalyx degradation (such as MMP-9 and cathepsin-B), compared to the control drug propofol [128]

We next performed a GIP secretion assay in an L cell model (GLUTag cells) (44), which, like other cancer-derived cell lines, also produces GIP (45)

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In a randomized trial in patients with obesity and cardiometabolic diseases, at 56 weeks, the mean weight loss was: Patients in the active treatment groups also had significant improvements in cardiovascular and metabolic risk factors such as waist circumference, systolic blood pressure, and total cholesterol/high-density lipoprotein cholesterol ratio