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Clinical Implications of Methylenetetrahydrofolate Reductase Mutations and Plasma Homocysteine Levels in Patients with Thromboembolic Occlusion

In addition to their roles in modulating the immune system, other functions have been attributed to exosomal cargo including enhanced vascular leakiness, fibronectin deposition, and delivery of soluble factors that are involved in ECM remodeling to support formation of a metastatic niche for tumor cells, including melanomas ( Figure 2 ) (104, 109112)

This could predominantly result in changes in: (i) thyroid gland weight and histological appearance

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This is the core pharmacological advantage of the IV route