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Hypoglycaemia risk is the primary safety consideration, along with potential joint swelling and carpal tunnel effects at higher doses

Common mild effects include nausea, constipation, bloating, and fatigue

Abbreviations ADA: American Diabetes Association ANVISA: Brazilian Health Regulatory Agency BMI: Body mass index CI: Confidence interval CKD: Chronic kidney disease CV: Cardiovascular CVD: Cardiovascular disease EASD: European Association for the Study of Diabetes eGFR: Estimated glomerular filtration rate ETD: Estimated treatment difference FDA: Food and Drug Administration GI: Gastrointestinal GLP-1 RA: Glucagon-like peptide 1 receptor agonist HbA1c: Glycated hemoglobin HOMA-: Homeostasis model assessment of -cell function HR: Hazard ratio kg: Kilograms kJ: Kilojoules m: Meter MACE: Major adverse cardiovascular event mg: Milligrams OR: Odds ratios PIONEER: Peptide Innovation for Early Diabetes Treatment SGLT2i: Sodium-glucose cotransporter 2 inhibitor SNAC: Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate T2D: Type 2 diabetes TZD: Thiazolidinedione UKPDS: United Kingdom Prospective Diabetes Study References International Diabetes Federation

(PubMed) Putignano S, Gareri P, Castagna A, et al

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