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Translational advances to date have been most pronounced for a defined subset of actionable heterogeneity features, including (i) truncal oncogenic drivers and convergent resistance mutations, (ii) tumor immune contexture, (particularly inflamed versus immune-excluded states), (iii) myeloid-mediated immunosuppressive niches within the tumor microenvironment, as a modifiable resistance axis, (iv) epigenetic and phenotypic plasticity that supports reversible drug-tolerant states, and (v) spatially organized hypoxic and stromal niches that influence drug delivery and immune accessibility

Participants were required to abstain from alcohol from 24 hours before until 24 hours after each dosing, refrain from caffeine and nicotine on imaging visit days and not drive or operate machinery from the time of dosing until 24 hours postdose

Int J Mol Sci (2021) 22(3):1273