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In the overall STEP program, nearly 10% of participants without diabetes and more than 30% of participants with type 2 diabetes experienced less than 5% weight loss, despite use of a potent GLP-1 receptor agonist plus lifestyle intervention

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Clinical evidence from large-scale trials, including the SUSTAIN programme, demonstrates that Ozempic does not typically cause high blood pressure

Beyond pancreatic effects, GLP-1 slows gastric emptying, which moderates postprandial glucose excursions, and acts on central nervous system receptors to promote satiety and reduce appetite