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For example, a co-crystallization strategy reveals that ML162 effectively targets all catalytic tetrad residues in GPX4 by interacting with Sec46, Gln81, Trp136, and Asn137, thereby completely obstructing the active site [218]

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Its structure is a faithful, full-sequence mimic of -MSH

The medication gets people started, but what happens between appointments matters enormously, said Dr