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Oral Mucosa The buccal mucosa is unique in that it has a rich vascular supply as well as excellent lymphatic drainage

Predisease individuals were defined as having RA-specific autoimmunity (ACPA assessed by testing positive for anticyclic citrullinated peptide 2 IgG autoantibody reactivity) but no past or present evidence of joint swelling according to phases C and D of the RA-at risk definition 45

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Given the lack of specific disease-modifying treatments for TIND, symptomatic management becomes paramount

This may result in undertreatment, a possible risk factor for disease progression and disease-related complications