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The obesity drug development landscape has developed rapidly amid increasing obesity prevalence rates where 40% and above of American adults are categorized as obese and there has been a doubling of obesity cases worldwide between 1975 and today, according to WHO

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These effects are more likely at higher doses, particularly above 3,000 mg per day, and taking supplements with food can help reduce gastrointestinal discomfort

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Virchows Arch A Pathol Anat Histopathol (1987) 410(5):3916.10.1007/BF00712758 170 MoranGWONeillCPadfieldPMcLaughlinJT