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More importantly, semaglutide and tirzepatide are not interchangeable on a milligram-for-milligram basis

[162] In March 2023, a Novo Nordisk official said, based on a randomized, double-blind study (NCT03548935 [163] ) funded by the company, that people using semaglutide to lose weight regained two-thirds of their original weight loss one year (52 weeks) after discontinuing use of the drug

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GI side effects were the most common and typically mild to moderate

Production of peptides can be performed through either chemical synthesis or biological methods such as recombinant deoxyribonucleic acid (rDNA) expression and fermentation 8