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More recently, nanocarriers have been engineered to co-deliver therapeutic genes, such as p53, regulatory RNAs (siRNA and miRNA targeting PD-L1, survivin, VEGF, B-cell lymphoma 2 (Bcl-2), and others), and naturally occurring cytolytic peptides, thereby enhancing therapeutic efficacy through gene silencing, apoptosis induction, and immune modulation (Li X

Regulatory status (US) Not FDA-approved Category 2 (2023) PCAC July 2026 Compound Melatonin What it is Hormone supplement Mechanism (in plain English) Shifts sleep timing via the circadian system

doi: 10.1016/j.ccell.2022.02.003 111 ZhaoMvan StratenDBroekmanMLDPratVSchiffelersRM

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