Injectable GLP-1 receptor agonists have no known direct pharmacokinetic interaction with levothyroxine, but they do slow gastric emptying, which theoretically could affect the absorption kinetics of oral medications
[DOI] [PubMed] [Google Scholar] 40.Buzzetti E., Pinzani M., Tsochatzis E
However, despite these advantages, the clinical use of native GLP-1 is significantly limited by its short plasma half-life (12 min), owing to rapid enzymatic degradation by DPP-4 and renal clearance
Your PlexusDx care team can review whether your current dose and medication formulationwhether Semaglutide Injection, Oral Semaglutide, or another compoundremains the best choice for your body
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