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Systemic Implications If an 85 mg/day human protocol were sustained over 8 weeks to match the murine intranasal timeline, it would cross into a biochemically hazardous profile: Hepatic Accumulation: The primary adverse effect of chronic copper toxicity is hepatotoxicity

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In addition, PQQ may induce tumor cell (A549, Neuro-2A and HCC-LM3) apoptosis by decreasing the expression of B-cell lymphoma 2 (11)