retatrutide weight loss trials results Experimental drug shows promising in trial Triple hormone receptor agonist retatrutide

PLoS ONE 8:e61965

There were infrequent reports of life-threatening anaphylaxis requiring emergent medical attention

In the context of GH and IGF-I physiology it can be concluded that 1) during childhood and adolescence the combined actions of GH and IGF-I in the presence of sufficient nutrition promote longitudinal growth and somatic maturation, 2) continued excess IGF-I activity in adulthood increases the risk for cardiovascular and neoplastic diseases and hence reduces longevity, 3) calorie restriction, which suppresses IGF-I activity and stimulates GH secretion, may promote longevity in human adults (82)

Statistical analysis used SigmaStat for Windows version 2.03 (SPSS, Chicago, IL, USA)

Intramuscular injections are often used first