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Studies in rodent systems reported relative oral bioavailability near 30 %, whereas intact TB-500 remained below 1 %

When combined with spironolactone (which actively retains potassium), the cumulative effect may raise potassium higher than either drug alonewhich is why lab monitoring is essential

Retrieved from Nguyen, H., Pellegrini, M

Continued approval for this indication may depend upon demonstration of further clinical benefit in studies