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PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024

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We developed a rapid endoplasmic reticulum (ER) immunoprecipitation strategy to isolate ER fractions and, by using it, identified SLC33A1 as an ER transporter that exports oxidized glutathione

These cell lines were then transplanted under the renal capsule of severely immunodeficient mice, and the xenografts were harvested five weeks after transplantation