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Accumulation of iron produces specific phospholipid hydroperoxides, which are counteracted endogenously by cells through the system xc - /GSH/GPX4 axis

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Journals of Gerontology: Series A

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For instance, microRNA-375-3p has been shown to alleviate salicylate-induced neuronal injury in vitro by targeting ELAVL4 and subsequently modulating NR2B expression and ROS production, pointing to potential upstream targets for intervention (Zhu et al., 2024)

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