Zhao T, Parikh P, Bhashyam S, Bolukoglu H, Poornima I, Shen YT, Shannon RP: Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts
doi 10.1371/journal.pone.0198046 91 MarottiVXuYBohns MichalowskiCZhangWDominguesIAmeraouiHet al
6.1 FA overload as a pathogenic catalyst Elevated levels of circulating FAs, derived predominantly from adipose lipolysis, DNL, and excessive dietary intake (238), represent the critical pathogenic drivers of GA
This contributes to adipose tissue dysfunction, whereas WAT inflammation and oxidative stress supervene, promoting the release of pro-inflammatory adipokines, leptin and adiponectin, along with enormous levels of cytokines (IL-6, IL-1b, TNF-) and NF-B activation, all ending in a cycle of sustained systemic insulin-resistant state [36,98,99,100]
Follow a gentle skincare routine: Use mild cleansers and avoid over-exfoliation, which can strip the skin barrier and worsen inflammation