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Therefore, the interplay between cysteine metabolism and other metabolic pathways, as well as the regulation of cysteine metabolism related enzymes and transporters, will be also addressed

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Nat Commun 14(1):2994

As a small molecule weighing approximately 529 Da, orforglipron binds to an allosteric pocket within the transmembrane domain of the GLP-1 receptor, stabilizing the active receptor conformation and driving downstream signaling through Gs protein coupling and cAMP accumulation