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The transgenic overexpression of HGF in the nervous system attenuates spinal motoneuronal death and axonal degeneration, delays onset of the disease, and prolongs the lifespan of SOD1-G93A mice (Sun et al., 2002)

Activation of central GLP-1 receptors enhances neuronal insulin signaling, improves glucose uptake, and supports mitochondrial energy production

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90,91 These impairments increase the risk of falls and foot ulcers due to unnoticed injuries

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