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Margis et al., 2008)

Glutathione peroxidase doesnt work in isolation

After 6 weeks of the dietary regimen, the mice underwent transient focal cerebral ischemia, and the study found that compared to the AL group, the active-phase intermittent fasting group exhibited better post-stroke motor and cognitive recovery and less infarction

However, in HTN and DM, chronic hyperglycemia, angiotensin II activation, and mitochondrial dysfunction exacerbate ROS production (Vejendla et al., 2024)

The overarching cardioprotective effect is achieved through the restoration of mitochondrial integrity and function, as evidenced by the recovery of key components (e.g., SCO1, CCO, and SOD1) and upregulating the biogenesis regulator PGC-1 [51, 204]