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Reasons for the differences in sensitivity may be due to the effect of the in vivo microenvironment

In addition, they may have other modes of action, as causing oxidative stress, genetic susceptibility, and epigenetic modifications (e.g., DNA methylation, miRNA) ( Specifically, some studies have demonstrated that EDCs such as bisphenol A (BPA), di-2-ethylhexyl phthalate (DEHP), dibutyl phthalate (DBP), and pesticides exert some of their endocrine-disrupting activity by influencing methylation patterns