Conclusions and future directions The lack of positive effects from CM supplementation within the existing literature is due to a number of factors, including the testing protocols not featuring a predominantly aerobic energy contribution, the lack of testretest reliability of exercise protocols, dosing strategy (i.e., amount and timing), and the recent discovery of quality control issues with some manufacturers stated citrulline:malate ratios
Its stability in an acidic gastric environment distinguishes it from other regenerative peptides (Sikiric et al., Curr Pharm Des 2018)
481 Monoacylglycerol lipase (MAGL) is an enzyme involved in the degradation of monoacylglycerols and the production of eicosanoids
This therapy works best when paired with healthy nutrition, movement, and provider-guided lifestyle changes
That said, if any adverse effect is suspected to be dose-related, the dose can be reduced