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While the effects on beta-cell mass, apoptosis and proliferation have also been demonstrated with liraglutide in young rodents (161, 162), they have not been shown to translate into a clinically significant effect in terms of the permanent prevention of diabetes progression, most likely because the effects on beta-cell mass are specific to younger animals and human beta-cells have a much lower, if any, capacity for regeneration (163, 164)

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In its clinical trial, QWO was injected three times, each 21 days apart, to produce results in patients

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