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Govender, M., Choonara, Y

These natural compounds frequently exhibit multi-faceted mechanisms of action, encompassing the modulation of monoaminergic neurotransmission, augmentation of neurotrophic signaling pathways, anti-inflammatory properties, antioxidant functions, and regulation of the HPA axis

Examples include acetaminophen (Tylenol) in high doses, certain antifungals, and some cholesterol-lowering medications

Since the FDA approved the first GLP-1 medicationByetta (exenatide)in 2005, clinicians have observed that GLP-1s not only support blood sugar control but also contribute to weight loss and other metabolic health improvements

10.1016/s0928-4257(97)89480-6 102 SelyeH.SzaboS