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The pro-inflammatory effect of leptin has been proven in animal models by Shore et al

Dosage adjustment of thyroid hormone replacements is still an art since inappropriate dosing can result in symptoms of overtreatment or undertreatment with further complications including cardiovascular problems, loss of bone density, and neurological disturbances

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[1],[41] Further, topical compositions containing S-acyl glutathione (about 0.110% by weight) or S-palmitoyl glutathione (about 39% by weight) admixed with other depigmenting and anti-oxidant substances have been prepared