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In contrast, an overproduction of ROS, outstripping the scavenging capacity of antioxidants, leads to oxidative stress, contributing to stone development ( The origins of ROS within the human body are multifarious, entailing the involvement of an array of signaling pathways

It is to note that both the cellular lipid hydroperoxides mediated by LOXs enzyme and autoxidized peroxyl radical-mediated LPO may contribute to initiate ferroptosis [38, 40]

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Mitochondrial division entails the formation of two spatially distinct types: midzone division, which occurs in the central region of the mitochondrion, and peripheral division, localized near its terminal regions (Kleele et al., 2021)

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