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Since interleukin 1-beta has been shown to be a key player in gouty inflammation (see under colchicine for acute gout, above), this agent has been studied in the treatment of gout attacks and appears to have been successful in preliminary study.14 Rilonacept (Arcalyst): This is a fusion protein which acts as a blocker of interleukin 1- beta, and it has a longer duration of action than Anakinra

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As a result of downregulation of Runt-related transcription factor 2 (Runx2) expression, ferroptosis inhibits osteogenic commitment and differentiation in mesenchymal stem cells and pre-osteoblasts, leading to a decrease in alkaline phosphatase and osteocalcin [10]

Huang X, Meng H, Shou Z et al (2024) Machine learning-mediated identification of ferroptosis-related genes in osteonecrosis of the femoral head

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