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Until well-designed human studies are conducted, McGuire and his co-authors concluded, the substance should be approached cautiously

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Without being bound by theory, it appears that Dihexa binds HGF better than HGF itself forming an active heterodimer of HGF:Dihexa

In addition, chronological aging of the skin is influenced by genetics, metabolism, and hormonal, immunological, cardiovascular, gastrointestinal, psychogenic (involving stress or affective disorders), degenerative, or neoplastic disease [16,17,18]