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Defective Nrf2 in CS-induced emphysema was attributed to a decreased level of DJ-1 that supports the stability of Nrf2 (72, 144), and to decreased histone deacetylase 2 (HDAC2) activity that increases the acetylation and inhibition of Nrf2 in CS-exposed lungs (145, 146)

Overall, Phase I metabolism represents the initial step in the biotransformation of drugs and foreign compounds, helping to prepare them for subsequent metabolic processes and elimination from the body

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Veeramani C, Alsaif MA, Al-Numair KS (2017) Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes