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A separate placebo-controlled trial in men with organic ED found MT-2 initiated subjectively reported erections in 12 of 19 injections versus only 1 of 21 placebo doses (Wessells et al., 1998)

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In recent years, more and more studies on UPS have been conducted, and we have recognized that UPS can play an important role in various renal diseases such as renal cell carcinoma[3], acute kidney injury[4], and renal fibrosis[5] through a variety of mechanisms