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Because of this, individuals supplementing this form of B12 often report improved quality of sleep, often will require slightly less sleep, and will not uncommonly report that they feel a bit more refreshed when waking in the morning

Gynecologic Oncology, 144(1), 159166

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Vitamin B12 deficiency has been linked to extreme tiredness lack or energy cancer cardiovascular disease, dementia decline in cognitive function nervous system damage anaemia mouth ulcers mental health conditions visual problems

Finally, apoptosis analysis was performed using a flow cytometer (CytoFlex SRT, Beckman Coulter)